Dihexa

Dihexa is a synthetic oligopeptide drug derived from angiotensin IV. It’s designed to cross the blood-brain barrier and is being researched for its potential to enhance cognitive function and promote neuroprotection

Dihexa works by binding with high affinity to hepatocyte growth factor (HGF) and activating the c-Met receptor, which triggers signaling pathways that promote neurogenesis (new neuron growth), synaptogenesis (formation of new synapses), and neural repair

It’s shown to be significantly more potent than brain-derived neurotrophic factor in preclinical studies, reportedly up to seven orders of magnitude more effective

Cognitive Benefits: Studies suggest it improves memory, learning, and cognitive function, particularly in conditions like Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative disorders. It enhances synaptic connectivity and dendritic spine formation, critical for learning and memory

Neuroprotective Effects: Dihexa may protect neurons from apoptosis (cell death) and reduce inflammation by decreasing pro-inflammatory cytokines while increasing anti-inflammatory ones

Potential Applications: It’s being investigated for Alzheimer’s, Parkinson’s, stroke recovery, and general cognitive enhancement